Hepatic Dose : No dose adjustment recommended. Dose as in normal renal functionĭialysed. Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death. Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Pain, swelling, and tenderness at the injection site may occur. The antidote to anticoagulant rodenticide is vitamin K1, a prescription drug. Although safe in opioid-naive patients, naloxone may precipitate severe acute withdrawal, which may in turn cause severe complications including cardiac arrhythmias, and acute respiratory distress syndrome (ARDS) 3, 4. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur. Activated charcoal should only be administered by a veterinarian. The usual antidote treatment for opioid-induced respiratory depression is naloxone. Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. Alternatively, 10 mg IV, IM or subcutaneously may be administered.
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